Kinase activity of mutant LRRK2 mediates neuronal toxicity
Kinase activity of mutant LRRK2 mediates neuronal toxicity
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Mutations in the the leucine-rich repeat kinase-2 (
LRRK2
) gene cause autosomal-dominant Parkinson disease and some cases of sporadic Parkinson disease. Here we found that LRRK2 kinase activity was regulated by GTP via the intrinsic GTPase Roc domain, and alterations of LRRK2 protein that reduced kinase activity of mutant LRRK2 corresponding...
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Full title
Kinase activity of mutant LRRK2 mediates neuronal toxicity
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TN_cdi_proquest_miscellaneous_864949877
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_864949877
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn1776
