Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Contents
Here we report that synaptic and extrasynaptic NMDA (
N
-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene expression as strongly...
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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
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TN_cdi_proquest_miscellaneous_864952272
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_864952272
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn835
