A new disulfide‐linked dimer of a single‐chain antibody fragment against human CD47 induces apoptosi...
A new disulfide‐linked dimer of a single‐chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor‐1α pathway
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Oxford, UK: Blackwell Publishing Ltd
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Language
English
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Publisher
Oxford, UK: Blackwell Publishing Ltd
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Scope and Contents
Contents
CD47 belongs to the immunoglobulin superfamily and is associated with β‐integrins. Recently it was reported that CD47 ligation rapidly induces apoptosis in B‐chronic lymphocytic leukemia (CLL) cells. Chronic lymphocytic leukemia is still an incurable hematological malignancy even with the novel therapeutic agents; therefore, new and effective agent...
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Full title
A new disulfide‐linked dimer of a single‐chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor‐1α pathway
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TN_cdi_proquest_miscellaneous_868030786
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_868030786
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ISSN
1347-9032
E-ISSN
1349-7006
DOI
10.1111/j.1349-7006.2011.01925.x
