CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A chaperone complex containing CSPα, Hsc70 and SGT binds to monomeric SNAP-25 and prevents its aggregation and degradation. Loss of CSPα inhibits SNARE complex formation.
A neuron forms thousands of presynaptic nerve terminals on its axons, far removed from the cell body. The protein CSPα resides in presynaptic terminals, where it forms a chaper...
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Full title
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity
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TN_cdi_proquest_miscellaneous_869570845
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_869570845
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2131
