Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic targe...
Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer
About this item
Full title
Author / Creator
Giamas, Georgios , Filipović, Aleksandra , Jacob, Jimmy , Messier, Walter , Zhang, Hua , Yang, Dongyun , Zhang, Wu , Shifa, Belul Assefa , Photiou, Andrew , Tralau-Stewart, Cathy , Castellano, Leandro , Green, Andrew R , Coombes, R Charles , Ellis, Ian O , Ali, Simak , Lenz, Heinz-Josef and Stebbing, Justin
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
This report identifies LMTK3 kinase as a regulator of ERα activity. LMTK3 exerts its effects through direct interaction and indirectly through regulation of PKC, AKT and FOXO3's effects on ERα transcription and stability. LMTK3 can modulate tamoxifen responses and is a poor prognostic factor in human breast cancer.
Therapies targeting estrogen r...
Alternative Titles
Full title
Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_871003761
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_871003761
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/nm.2351
