Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutr...
Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization
About this item
Full title
Author / Creator
Igawa, Tomoyuki , Ishii, Shinya , Tachibana, Tatsuhiko , Maeda, Atsuhiko , Higuchi, Yoshinobu , Shimaoka, Shin , Moriyama, Chifumi , Watanabe, Tomoyuki , Takubo, Ryoko , Doi, Yoshiaki , Wakabayashi, Tetsuya , Hayasaka, Akira , Kadono, Shoujiro , Miyazaki, Takuya , Haraya, Kenta , Sekimori, Yasuo , Kojima, Tetsuo , Nabuchi, Yoshiaki , Aso, Yoshinori , Kawabe, Yoshiki and Hattori, Kunihiro
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The typical therapeutic antibody binds only two target antigen molecules during its lifetime. Igawa
et al
. describe a method for engineering antibody recycling
in vivo
, suggesting an approach to reduce the size and/or frequency of dosage with therapeutic antibodies.
For many antibodies, each antigen-binding site binds to only one a...
Alternative Titles
Full title
Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization
Authors, Artists and Contributors
Author / Creator
Ishii, Shinya
Tachibana, Tatsuhiko
Maeda, Atsuhiko
Higuchi, Yoshinobu
Shimaoka, Shin
Moriyama, Chifumi
Watanabe, Tomoyuki
Takubo, Ryoko
Doi, Yoshiaki
Wakabayashi, Tetsuya
Hayasaka, Akira
Kadono, Shoujiro
Miyazaki, Takuya
Haraya, Kenta
Sekimori, Yasuo
Kojima, Tetsuo
Nabuchi, Yoshiaki
Aso, Yoshinori
Kawabe, Yoshiki
Hattori, Kunihiro
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_874183688
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_874183688
Other Identifiers
ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.1691
