Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
BRCA2 is a tumor suppressor that interacts with RAD51 and functions in homologous recombination, but understanding its precise functions has been hampered by difficulties in purifying such a large protein. Now purified full-length human BRCA2 is shown to bind ∼6 molecules of RAD51 and to promote RAD51 binding to RPA-covered ssDNA in a manner stimul...
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Full title
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA
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TN_cdi_proquest_miscellaneous_874196242
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_874196242
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.1904
