Genome-wide genetic association of complex traits in heterogeneous stock mice
Genome-wide genetic association of complex traits in heterogeneous stock mice
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Difficulties in fine-mapping quantitative trait loci (QTLs) are a major impediment to progress in the molecular dissection of complex traits in mice. Here we show that genome-wide high-resolution mapping of multiple phenotypes can be achieved using a stock of genetically heterogeneous mice. We developed a conservative and robust bootstrap analysis to map 843 QTLs with an average 95% confidence interval of 2.8 Mb. The QTLs contribute to variation in 97 traits, including models of human disease (asthma, type 2 diabetes mellitus, obesity and anxiety) as well as immunological, biochemical and hematological phenotypes. The genetic architecture of almost all phenotypes was complex, with many loci each contributing a small proportion to the total variance. Our data set, freely available at
http://gscan.well.ox.ac.uk
, provides an entry point to the functional characterization of genes involved in many complex traits....
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Full title
Genome-wide genetic association of complex traits in heterogeneous stock mice
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TN_cdi_proquest_miscellaneous_877597618
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_877597618
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng1840
