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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_884426156

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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London: Nature Publishing Group UK

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Serine biosynthesis target in breast cancer
An
in vivo
RNAi screen of metabolic enzymes and transporters is used to identify, among other genes, phosphoglycerate dehydrogenase (PHGDH) as a gene required for breast tumour growth. PHGDH resides in a region of chromosome 1p that is often amplified in breast cancers, leading to PHGDH overexpre...

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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

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TN_cdi_proquest_miscellaneous_884426156

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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_884426156

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature10350

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