Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and fe...
Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity
About this item
Full title
Author / Creator
Diano, Sabrina , Liu, Zhong-Wu , Jeong, Jin Kwon , Dietrich, Marcelo O , Ruan, Hai-Bin , Kim, Esther , Suyama, Shigetomo , Kelly, Kaitlin , Gyengesi, Erika , Arbiser, Jack L , Belsham, Denise D , Sarruf, David A , Schwartz, Michael W , Bennett, Anton M , Shanabrough, Marya , Mobbs, Charles V , Yang, Xiaoyong , Gao, Xiao-Bing and Horvath, Tamas L
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Tamas Horvath and his colleagues show that in states of obesity activation of the transcription factor PPAR-γ in POMC neurons occurs, resulting in an increase in peroxisome proliferation. This cellular event leads to reduced ROS levels in these cells, decreased neuronal firing and increased food intake. They also show that central pharmacological i...
Alternative Titles
Full title
Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity
Authors, Artists and Contributors
Author / Creator
Liu, Zhong-Wu
Jeong, Jin Kwon
Dietrich, Marcelo O
Ruan, Hai-Bin
Kim, Esther
Suyama, Shigetomo
Kelly, Kaitlin
Gyengesi, Erika
Arbiser, Jack L
Belsham, Denise D
Sarruf, David A
Schwartz, Michael W
Bennett, Anton M
Shanabrough, Marya
Mobbs, Charles V
Yang, Xiaoyong
Gao, Xiao-Bing
Horvath, Tamas L
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_888337469
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_888337469
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2421
