p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis
p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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The activation of stress kinases, such as p38 MAPK, is believed to be detrimental to normal cellular processes. However, Umut Ozcan and his colleagues now show that p38 MAPK is actually beneficial, as in mice it increases the mRNA stability and nuclear localization of Xbp1s, a crucial factor in resolving endoplasmic reticulum stress and improving g...
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p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis
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TN_cdi_proquest_miscellaneous_898206433
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_898206433
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2449
