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Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-aden...

Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-aden...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_901006628

Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)

About this item

Full title

Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)

Publisher

Netherlands

Journal title

Molecular and cellular biochemistry, 2011-12, Vol.358 (1-2), p.229-239

Language

English

Formats

Publication information

Publisher

Netherlands

More information

Scope and Contents

Contents

We previously found that homocysteine (Hcy) induced plasma membrane flip-flop, apoptosis, and necrosis in cardiomyocytes. Inactivation of flippase by Hcy induced membrane flip-flop, while apoptosis was induced via a NOX2-dependent mechanism. It has been suggested that S-adenosylhomocysteine (SAH) is the main causative factor in hyperhomocysteinemia...

Alternative Titles

Full title

Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_901006628

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_901006628

Other Identifiers

E-ISSN

1573-4919

DOI

10.1007/s11010-011-0973-4

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