Both IL-12p70 and IL-23 Are Synthesized During Active Crohn's Disease and Are Down-regulated by Trea...
Both IL-12p70 and IL-23 Are Synthesized During Active Crohn's Disease and Are Down-regulated by Treatment with Anti-IL-12 p40 Monoclonal Antibody
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Oxford, UK: Oxford University Press
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Language
English
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Oxford, UK: Oxford University Press
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Contents
Interleukin (IL)-12p70 and IL-23 are key T helper-1 (TH1) cytokines that drive the inflammation seen in numerous models of intestinal inflammation. These molecules contain an identical p40 chain that is bound to a p35 chain in IL-12 and a p19 chain in IL-23, making both potentially susceptible to modulation by an anti-IL-12p40 monoclonal antibody (...
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Full title
Both IL-12p70 and IL-23 Are Synthesized During Active Crohn's Disease and Are Down-regulated by Treatment with Anti-IL-12 p40 Monoclonal Antibody
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TN_cdi_proquest_miscellaneous_902337854
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_902337854
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ISSN
1078-0998
E-ISSN
1536-4844
DOI
10.1097/01.MIB.0000194183.92671.b6
