Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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The receptor sortilin has been implicated in pro-apoptotic signaling of proneurotrophins. In this study, the authors uncover another role for sortilin in neurotrophin signaling: it interacts with Trk family receptors to promote their anterograde transport to nerve endings, thereby enhancing neurotrophin-dependent cell survival.
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Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
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TN_cdi_proquest_miscellaneous_904465559
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_904465559
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.2689
