ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target ce...
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis
About this item
Full title
Author / Creator
Maul-Pavicic, Andrea , Chiang, Samuel C.C , Rensing-Ehl, Anne , Jessen, Birthe , Fauriat, Cyril , Wood, Stephanie M , Sjöqvist, Sebastian , Hufnagel, Markus , Schulze, Ilka , Bass, Thilo , Schamel, Wolfgang W , Fuchs, Sebastian , Pircher, Hanspeter , McCarl, Christie-Ann , Mikoshiba, Katsuhiko , Schwarz, Klaus , Feske, Stefan , Bryceson, Yenan T and Ehl, Stephan
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Lymphocytes mediate cytotoxicity by polarized release of the contents of cytotoxic granules toward their target cells. Here, we have studied the role of the calcium release-activated calcium channel ORAI1 in human lymphocyte cytotoxicity. Natural killer (NK) cells obtained from an ORAI1-deficient patient displayed defective store-operated Ca²⁺ entr...
Alternative Titles
Full title
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis
Authors, Artists and Contributors
Author / Creator
Chiang, Samuel C.C
Rensing-Ehl, Anne
Jessen, Birthe
Fauriat, Cyril
Wood, Stephanie M
Sjöqvist, Sebastian
Hufnagel, Markus
Schulze, Ilka
Bass, Thilo
Schamel, Wolfgang W
Fuchs, Sebastian
Pircher, Hanspeter
McCarl, Christie-Ann
Mikoshiba, Katsuhiko
Schwarz, Klaus
Feske, Stefan
Bryceson, Yenan T
Ehl, Stephan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_904470938
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_904470938
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1013285108
