Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Rare cells with the properties of stem cells are integral to the development and perpetuation of leukaemias. A defining characteristic of stem cells is their capacity to self-renew, which is markedly extended in leukaemia stem cells. The underlying molecular mechanisms, however, are largely unknown. Here we demonstrate that expression of the cell-c...
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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
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TN_cdi_proquest_miscellaneous_904472934
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_904472934
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ISSN
0028-0836
E-ISSN
1476-4687,1476-4679
DOI
10.1038/nature07618
