LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key histone modifier that participates in the maintenance of pluripotency through the regulation of bivalent domains, a chromatin environment present at the regulatory regions of developmental genes that contains both H3K4 di/trimethylation and H3K27 trimethylation...
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LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
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TN_cdi_proquest_miscellaneous_904474154
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_904474154
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2246
