Development of Therapeutic siRNAs for Pachyonychia Congenita
Development of Therapeutic siRNAs for Pachyonychia Congenita
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Publisher
United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Scope and Contents
Contents
Pachyonychia congenita (PC) is an autosomal-dominant keratin disorder where the most painful, debilitating aspect is plantar keratoderma. PC is caused by mutations in one of four keratin genes; however, most patients carry K6a mutations. Knockout mouse studies suggest that ablation of one of the several K6 genes can be tolerated owing to compensato...
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Full title
Development of Therapeutic siRNAs for Pachyonychia Congenita
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TN_cdi_proquest_miscellaneous_904474532
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_904474532
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ISSN
0022-202X
E-ISSN
1523-1747
DOI
10.1038/sj.jid.5701040
