EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure amo...
EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
EspR is a transcriptional regulator that activates the ESX-1 secretion system during Mycobacterium tuberculosis infection and is critical for pathogenesis. It is unique among DNA-binding proteins as it is secreted as part of a feedback regulatory loop that serves to mitigate transcriptional activity. Here we report the crystal structure of a functi...
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EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins
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TN_cdi_proquest_miscellaneous_904486233
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_904486233
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1110242108
