A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
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Jirawatnotai, Siwanon , Hu, Yiduo , Michowski, Wojciech , Elias, Joshua E. , Becks, Lisa , Bienvenu, Frederic , Zagozdzon, Agnieszka , Goswami, Tapasree , Wang, Yaoyu E. , Clark, Alan B. , Kunkel, Thomas A. , van Harn, Tanja , Xia, Bing , Correll, Mick , Quackenbush, John , Livingston, David M. , Gygi, Steven P. and Sicinski, Piotr
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cyclin D1 role in DNA repair
Cyclin D1 has a crucial role in the cell cycle and is often overexpressed in cancer. Piotr Sicinski and colleagues report an unexpected function for cyclin D1 in DNA repair that is independent of its known CDK-dependent role. Cyclin D1 is recruited to sites of DNA damage and binds to RAD51, a key DNA recombinase that...
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A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
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TN_cdi_proquest_miscellaneous_904486903
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_904486903
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10155
