Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming an...
Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ‘stemness’ via the bone morphogenetic protein pathway
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Publisher
London: BMJ Publishing Group Ltd and British Society of Gastroenterology
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Language
English
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Publisher
London: BMJ Publishing Group Ltd and British Society of Gastroenterology
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BackgroundPromoter hypermethylation is an important and potentially reversible mechanism of tumour suppressor gene silencing in cancer. Compounds that demethylate tumour suppressor genes and induce differentiation of cancer cells, but do not have toxic side effects, would represent an exciting option in cancer therapy. Statins are cholesterol-lower...
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Full title
Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell ‘stemness’ via the bone morphogenetic protein pathway
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TN_cdi_proquest_miscellaneous_907180930
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_907180930
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ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gut.2011.237495
