Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Washington, DC: American Association for the Advancement of Science
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Contents
Many biological processes are regulated through the selective dephosphorylation of proteins. Protein serine-threonine phosphatases are assembled from catalytic subunits bound to diverse regulatory subunits that provide substrate specificity and subcellular localization. We describe a small molecule, guanabenz, that bound to a regulatory subunit of...
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Full title
Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
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TN_cdi_proquest_miscellaneous_907932327
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_907932327
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1201396
