Long Unfolded Linkers Facilitate Membrane Protein Import Through the Nuclear Pore Complex
Long Unfolded Linkers Facilitate Membrane Protein Import Through the Nuclear Pore Complex
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Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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Active nuclear import of soluble cargo involves transport factors that shuttle cargo through the nuclear pore complex (NPC) by binding to phenylalanine-glycine (FG) domains. How nuclear membrane proteins cross through the NPC to reach the inner membrane is presently unclear. We found that at least a 120-residue-long intrinsically disordered linker...
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Full title
Long Unfolded Linkers Facilitate Membrane Protein Import Through the Nuclear Pore Complex
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TN_cdi_proquest_miscellaneous_907953724
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_907953724
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1205741
