High order chromatin architecture shapes the landscape of chromosomal alterations in cancer
High order chromatin architecture shapes the landscape of chromosomal alterations in cancer
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Copy-number changes, point mutations and rearrangements are all usually found in cancer genomes, but their relative frequencies are highly variable. Using statistical approaches to model different processes, Fudenberg
et al
. find that copy number gain and loss is influenced by the three-dimensional organization of the genome in the nucleus.<...
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Full title
High order chromatin architecture shapes the landscape of chromosomal alterations in cancer
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TN_cdi_proquest_miscellaneous_911934514
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_911934514
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ISSN
1087-0156
E-ISSN
1546-1696
DOI
10.1038/nbt.2049
