Aspartate 112 is the selectivity filter of the human voltage-gated proton channel
Aspartate 112 is the selectivity filter of the human voltage-gated proton channel
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Aspartate key to proton selectivity
Voltage-gated proton channels are considered completely selective for protons — no evidence exists for the permeation of ions other than H
+
. A study of the underlying mechanism of the high selectivity of the human voltage-gated proton channel reveals an Asp112 residue as the selectivity filter. When th...
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Full title
Aspartate 112 is the selectivity filter of the human voltage-gated proton channel
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TN_cdi_proquest_miscellaneous_911940568
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_911940568
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10557
