HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
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Author / Creator
Goldstone, David C. , Ennis-Adeniran, Valerie , Hedden, Joseph J. , Groom, Harriet C. T. , Rice, Gillian I. , Christodoulou, Evangelos , Walker, Philip A. , Kelly, Geoff , Haire, Lesley F. , Yap, Melvyn W. , de Carvalho, Luiz Pedro S. , Stoye, Jonathan P. , Crow, Yanick J. , Taylor, Ian A. and Webb, Michelle
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Antiretroviral role for SAMHD1 protein
Mutations in SAMHD1 protein are associated with the human autoimmune disease Aicardi–Goutières syndrome, and SAMHD1 was recently shown to be responsible for restriction of HIV-1 replication in myeloid cells. Ian Taylor and colleagues reveal a previously unknown function of SAMHD1 that could explain its anti...
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Full title
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
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TN_cdi_proquest_miscellaneous_911946375
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_911946375
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10623
