TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3
TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Using a membrane-tethered, genetically encoded Ca
2+
indicator, the authors describe a novel Ca
2+
signal in hippocampal astrocytes. These 'spotty' Ca
2+
signals were found to be mediated by astrocytic TRPA1 channels. Decreasing astrocyte resting Ca
2+
, regulated by TRPA1 channels, decreased interneuron inhibitory synapse e...
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TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3
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TN_cdi_proquest_miscellaneous_912641598
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_912641598
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ISSN
1097-6256,1546-1726
E-ISSN
1546-1726
DOI
10.1038/nn.3000