Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28
Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Lin28 prevents the processing of pre-let-7 RNAs, but it is not clear where the Lin28 RNA binding domains interact with the RNA. The NMR structure of the Lin28 zinc knuckles with a short RNA motif reveals that each knuckle interacts with an AG dinucleotide, allowing the determination of a consensus motif for pre-let-7 recognition.
Lin28 inhibits...
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Full title
Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28
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TN_cdi_proquest_miscellaneous_914667371
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_914667371
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.2202
