APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The anaphase-promoting complex or cyclosome (APC/C) initiates mitotic exit by ubiquitylating cell-cycle regulators such as cyclin B1 and securin. Lys 48-linked ubiquitin chains represent the canonical signal targeting proteins for degradation by the proteasome, but they are not required for the degradation of cyclin B1. Lys 11-linked ubiquitin chai...
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APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1
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TN_cdi_proquest_miscellaneous_919949274
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_919949274
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2425
