Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs...
Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types
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Full title
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The unprecedented genetic diversity found at vertebrate MHC (major histocompatibility complex) loci influences susceptibility to most infectious and autoimmune diseases. The evolutionary explanation for how these polymorphisms are maintained has been controversial. One leading explanation, antagonistic coevolution (also known as the Red Queen), pos...
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Full title
Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types
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Record Identifier
TN_cdi_proquest_miscellaneous_925716981
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_925716981
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1112633109
