KLOTHO methylation is linked to uremic toxins and chronic kidney disease
KLOTHO methylation is linked to uremic toxins and chronic kidney disease
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Publisher
United States: Elsevier Inc
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Language
English
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Publisher
United States: Elsevier Inc
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Scope and Contents
Contents
Epigenetic regulation plays a major role in uremic toxin-induced chronic kidney disease (CKD) progression. The KLOTHO protein is a key modulator of homeostasis in renal function. Uremic toxin accumulation can induce DNA methyltransferase (DNMT) protein expression, which is involved in the silencing of KLOTHO through hypermethylation. Treatment with...
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Full title
KLOTHO methylation is linked to uremic toxins and chronic kidney disease
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TN_cdi_proquest_miscellaneous_928910146
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_928910146
Other Identifiers
ISSN
0085-2538
E-ISSN
1523-1755
DOI
10.1038/ki.2011.461
