Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
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Author / Creator
Koivunen, Peppi , Lee, Sungwoo , Duncan, Christopher G. , Lopez, Giselle , Lu, Gang , Ramkissoon, Shakti , Losman, Julie A. , Joensuu, Päivi , Bergmann, Ulrich , Gross, Stefan , Travins, Jeremy , Weiss, Samuel , Looper, Ryan , Ligon, Keith L. , Verhaak, Roel G. W. , Yan, Hai and Kaelin Jr, William G.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
The (
R
)-enantiomer of 2-hydroxyglutarate, which is produced when IDH is mutated in human tumours, is shown to stimulate the activity of the EGLN prolyl 4-hydroxylases, leading to diminished levels of HIF and enhanced human astrocyte proliferation.
Cancer induction by isocitrate dehydrogenase mutation
Mutations in the isocitrate dehydr...
Alternative Titles
Full title
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
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Record Identifier
TN_cdi_proquest_miscellaneous_940835285
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_940835285
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/nature10898
