Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin...
Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
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Publisher
London: BMJ Publishing Group Ltd and European League Against Rheumatism
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Language
English
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Publisher
London: BMJ Publishing Group Ltd and European League Against Rheumatism
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More information
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Contents
Introduction Inflammation is a major risk factor for systemic bone loss. Proinflammatory cytokines like tumour necrosis factor (TNF) affect bone homeostasis and induce bone loss. It was hypothesised that impaired bone formation is a key component in inflammatory bone loss and that Dkk-1, a Wnt antagonist, is a strong inhibitor of osteoblast-mediate...
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Full title
Neutralisation of Dkk-1 protects from systemic bone loss during inflammation and reduces sclerostin expression
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TN_cdi_proquest_miscellaneous_954592468
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_954592468
Other Identifiers
ISSN
0003-4967
E-ISSN
1468-2060
DOI
10.1136/ard.2010.132852
