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Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_954608478

Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

About this item

Full title

Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

Publisher

Berlin/Heidelberg: Springer-Verlag

Journal title

Human genetics, 2010-12, Vol.128 (6), p.577-588

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer-Verlag

More information

Scope and Contents

Contents

The human
TRIM5
genes encodes a retroviral restriction factor (TRIM5α). Evolutionary analyses of this gene in mammals have revealed a complex and multifaceted scenario, suggesting that
TRIM5
has been the target of exceptionally strong selective pressures, possibly exerted by recurrent waves of retroviral infections.
TRIM5
displays...

Alternative Titles

Full title

Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_954608478

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_954608478

Other Identifiers

ISSN

0340-6717

E-ISSN

1432-1203

DOI

10.1007/s00439-010-0884-6

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