Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML–BFM...
Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML–BFM and DCOG study groups
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Author / Creator
Damm, F , Thol, F , Hollink, I , Zimmermann, M , Reinhardt, K , van den Heuvel-Eibrink, M M , Zwaan, C M , de Haas, V , Creutzig, U , Klusmann, J-H , Krauter, J , Heuser, M , Ganser, A , Reinhardt, D and Thiede, C
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mutations in the NADP
+
-dependent isocitrate dehydrogenase genes 1 and 2 (
IDH1
and
IDH2
) have recently been found in adult acute myeloid leukemia (AML) patients with a prevalence rising up to 33%. To investigate the frequency of
IDH1
/
2
mutations in pediatric AML, we characterized the mutational hotspot (exon 4) of...
Alternative Titles
Full title
Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML–BFM and DCOG study groups
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Record Identifier
TN_cdi_proquest_miscellaneous_968169598
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_968169598
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2011.142
