2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
About this item
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Author / Creator
Choi, Changho , Ganji, Sandeep K , DeBerardinis, Ralph J , Hatanpaa, Kimmo J , Rakheja, Dinesh , Kovacs, Zoltan , Yang, Xiao-Li , Mashimo, Tomoyuki , Raisanen, Jack M , Marin-Valencia, Isaac , Pascual, Juan M , Madden, Christopher J , Mickey, Bruce E , Malloy, Craig R , Bachoo, Robert M and Maher, Elizabeth A
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Mutations in isocitrate dehydrogenases 1 and 2 (
IDH1
and
IDH2
) in the majority of people with grade 2 and 3 gliomas is associated with elevated levels of 2-hydroxyglutarate (2HG) within the tumor. As harboring
IDH1
or
IDH2
mutations confers a considerable survival benefit in these individuals, there has been considerable i...
Alternative Titles
Full title
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
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Record Identifier
TN_cdi_proquest_miscellaneous_992831493
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_992831493
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2682
