In the late 1970s, researchers discovered a mitochondrial calcium influx "set point," a point at which calcium levels become high enough in the cytoplasm (intracellular fluid) to trigger calcium uptake into mitochondria. The set point was determined to be about 3 muM. Dr. [Muniswamy Madesh] and colleagues previously discovered that below the set po...

Subcellular Fractions; Temple scientists studying mitochondrial calcium handling yield new disease targets