"FIG. 2 shows the global analysis of their transcriptome by microarrays that we performed. In all three strains we found that the dnaK operon and the cIpB gene were overexpressed (data not shown for NCC2923). The expression levels of each gene are expressed versus the expression level of the wt B. longum strain NCC2705, in exponential growth phase (A and D), in exponential phase after a 7-minute heat-shock (B and E), and in stationary phase (C and F). Genes of the dnaK operon are shown in black (BL0516=hspR, BL0517=dnaJ, BL0519=grpE, and BL0520=dnaK), cIpB (=BL1250) in white. The other genes are depicted in grey. "FIG. 5 shows that the constitutive over-expression of the HspR regulator in the wt strain confers an increased heat-sensitivity to the wt strain. The figure shows the viability loss after a 13-minute heat-shock at 59.degree. C. and the effect of the complementation of the wt strain by the wt hspR gene. wt=NCC2705; error bars show the standard deviation from 3 replicates; *, beyond detection limit." URL and more information on this patent application, see: [Berger, Bernard]; Rezzonico, [Ernea]; Arigoni, [Fabrizio]. Stress Tolerant Bifidobacteria. Filed April 22, 2014 and posted August 21, 2014. Patent URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=%2Fnetahtml%2FPTO%2Fsearch-adv.html&r=2325&p=47&f=G&l=50&d=PG01&S1=20140814.PD.&OS=PD/20140814&RS=PD/20140814...

Nestec S.a.; "Stress Tolerant Bifidobacteria" in Patent Application Approval Process