Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
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Author / Creator
Nakano, H , Sakon, S , Koseki, H , Takemori, T , Tada, K , Matsumoto, M , Munechika, E , Sakai, T , Shirasawa, T , Akiba, H , Kobata, T , Santee, S M , Ware, C F , Rennert, P D , Taniguchi, M , Yagita, H and Okumura, K
Publisher
United States: National Acad Sciences
Journal title
Language
English
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Publisher
United States: National Acad Sciences
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Scope and Contents
Contents
TRAF5 [tumor necrosis factor (TNF) receptor-associated factor 5] is implicated in NF-κB and c-Jun NH 2 -terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-β receptor. To investigate the functional role of TRAF5 in vivo , we generated TRAF5-deficient mice...
Alternative Titles
Full title
Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
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Record Identifier
TN_cdi_pubmed_primary_10449775
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_10449775
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.96.17.9803
