Constitutive Activation of Tethered-Peptide/Corticotropin-Releasing Factor Receptor Chimeras
Constitutive Activation of Tethered-Peptide/Corticotropin-Releasing Factor Receptor Chimeras
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Scope and Contents
Contents
Constitutive activity, or ligand-independent activity, of mutant G protein-coupled receptors (GPCRs) has been described extensively and implicated in the pathology of many diseases. Using the corticotropin-releasing factor (CRF) receptor and the thrombin receptor as a model, we present a ligand-dependent constitutive activation of a GPCR. A chimera...
Alternative Titles
Full title
Constitutive Activation of Tethered-Peptide/Corticotropin-Releasing Factor Receptor Chimeras
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Record Identifier
TN_cdi_pubmed_primary_10963687
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_10963687
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.97.18.10277
