STAT4 Serine Phosphorylation Is Critical for IL-12-Induced IFN-γ Production but not for Cell Prolife...
STAT4 Serine Phosphorylation Is Critical for IL-12-Induced IFN-γ Production but not for Cell Proliferation
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
T helper 1 (TH1) differentiation and IFN-γ production are crucial in cell-mediated immune responses. IL-12 is an important regulator of this process and mediates its effects through signal transducer and activator of transcription 4 (STAT4). IFN-γ production is also regulated by the p38 mitogen-activated kinase pathway, although the mechanisms are...
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Full title
STAT4 Serine Phosphorylation Is Critical for IL-12-Induced IFN-γ Production but not for Cell Proliferation
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TN_cdi_pubmed_primary_12213961
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_12213961
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.182618999
