Disruption of Abcg5 and Abcg8 in Mice Reveals Their Crucial Role in Biliary Cholesterol Secretion
Disruption of Abcg5 and Abcg8 in Mice Reveals Their Crucial Role in Biliary Cholesterol Secretion
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Cholesterol and other sterols exit the body primarily by secretion into bile. In patients with sitosterolemia, mutations in either of two ATP-binding cassette (ABC) half-transporters, ABCG5 or ABCG8, lead to reduced secretion of sterols into bile, implicating these transporters in this process. To elucidate the roles of ABCG5 and ABCG8 in the traff...
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Full title
Disruption of Abcg5 and Abcg8 in Mice Reveals Their Crucial Role in Biliary Cholesterol Secretion
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TN_cdi_pubmed_primary_12444248
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_12444248
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.252582399
