Selective Killing of Cancer Cells by β-Lapachone: Direct Checkpoint Activation as a Strategy against...
Selective Killing of Cancer Cells by β-Lapachone: Direct Checkpoint Activation as a Strategy against Cancer
About this item
Full title
Author / Creator
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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More information
Scope and Contents
Contents
Most chemotherapeutic drugs kill cancer cells by indirectly activating checkpoint-mediated apoptosis after creating nonselective damage to DNA or microtubules, which accounts for their toxicity toward normal cells. We seek to target cancer cells by directly activating checkpoint regulators without creating such damage. Here, we show that β-lapachon...
Alternative Titles
Full title
Selective Killing of Cancer Cells by β-Lapachone: Direct Checkpoint Activation as a Strategy against Cancer
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmed_primary_12598645
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_12598645
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0538044100
