The Primary Mechanism of Attenuation of Bacillus Calmette-Guérin Is a Loss of Secreted Lytic Functio...
The Primary Mechanism of Attenuation of Bacillus Calmette-Guérin Is a Loss of Secreted Lytic Function Required for Invasion of Lung Interstitial Tissue
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Author / Creator
Hsu, Tsungda , Hingley-Wilson, Suzanne M. , Chen, Bing , Chen, Mei , Dai, Annie Z. , Morin, Paul M. , Marks, Carolyn B. , Padiyar, Jeevan , Goulding, Celia , Gingery, Mari , Eisenberg, David , Russell, Robert G. , Derrick, Steven C. , Collins, Frank M. , Morris, Sheldon L. , King, C. Harold and Jacobs, William R.
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Tuberculosis remains a leading cause of death worldwide, despite the availability of effective chemotherapy and a vaccine. Bacillus Calmette-Guérin (BCG), the tuberculosis vaccine, is an attenuated mutant of Mycobacterium bovis that was isolated after serial subcultures, yet the functional basis for this attenuation has never been elucidated. A sin...
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Full title
The Primary Mechanism of Attenuation of Bacillus Calmette-Guérin Is a Loss of Secreted Lytic Function Required for Invasion of Lung Interstitial Tissue
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TN_cdi_pubmed_primary_14557547
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_14557547
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1635213100
