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The Irinotecan/5-Fluorouracil Combination Induces Apoptosis and Enhances Manganese Superoxide Dismut...

The Irinotecan/5-Fluorouracil Combination Induces Apoptosis and Enhances Manganese Superoxide Dismut...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_15886469

The Irinotecan/5-Fluorouracil Combination Induces Apoptosis and Enhances Manganese Superoxide Dismutase Activity in HT-29 Human Colon Carcinoma Cells

About this item

Full title

The Irinotecan/5-Fluorouracil Combination Induces Apoptosis and Enhances Manganese Superoxide Dismutase Activity in HT-29 Human Colon Carcinoma Cells

Publisher

Basel, Switzerland: Karger

Journal title

Chemotherapy (Basel), 2005-05, Vol.51 (2-3), p.93-102

Language

English

Formats

Publication information

Publisher

Basel, Switzerland: Karger

More information

Scope and Contents

Contents

Background: We examined whether induction of apoptosis and Mn-superoxide dismutase (Mn-SOD) and Cu,Zn-superoxide dismutase (Cu,Zn-SOD) activities were involved in the greater cytotoxicity of the irinotecan (CPT-11)/5-fluorouracil (5-FU) combination for human colon cancer cells when compared to both drugs alone. Methods: HT-29 and SNU-C4 human colon...

Alternative Titles

Full title

The Irinotecan/5-Fluorouracil Combination Induces Apoptosis and Enhances Manganese Superoxide Dismutase Activity in HT-29 Human Colon Carcinoma Cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmed_primary_15886469

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_15886469

Other Identifiers

ISSN

0009-3157

E-ISSN

1421-9794

DOI

10.1159/000085617

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