Activation of Naïve B Lymphocytes via CD81, a Pathogenetic Mechanism for Hepatitis C Virus-Associate...
Activation of Naïve B Lymphocytes via CD81, a Pathogenetic Mechanism for Hepatitis C Virus-Associated B Lymphocyte Disorders
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Infection with hepatitis C virus (HCV), a leading cause of chronic liver diseases, can associate with B lymphocyte proliferative disorders, such as mixed cryoglobulinemia and non-Hodgkin lymphoma. The major envelope protein of HCV (HCV-E2) binds, with high affinity CD81, a tetraspanin expressed on several cell types. Here, we show that engagement o...
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Full title
Activation of Naïve B Lymphocytes via CD81, a Pathogenetic Mechanism for Hepatitis C Virus-Associated B Lymphocyte Disorders
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TN_cdi_pubmed_primary_16339892
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_16339892
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0509402102
