A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltrat...
A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats
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England
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English
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England
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alpha(4)beta(1) and alpha(4)beta(7) integrins are preferentially expressed on eosinophils and mononuclear leukocytes and play critical roles in their recruitment to inflammatory sites. We investigated the effects of TR14035, a small molecule, alpha(4)beta(1)/alpha(4)beta(7) dual antagonist, in a rat model of allergic asthma. Actively sensitized rat...
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A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats
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TN_cdi_pubmed_primary_16432509
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_16432509
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0007-1188
