Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10...
Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation
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United States: National Academy of Sciences
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English
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United States: National Academy of Sciences
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Sudden cardiac death due to abnormal heart rhythm kills 400,000-460,000 Americans each year. To identify genes that regulate heart rhythm, we are developing a screen that uses mouse embryonic stem cells (mESCs) with gene disruptions that can be differentiated into cardiac cells for phenotyping. Here, we show that the heterozygous disruption of the...
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Full title
Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation
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TN_cdi_pubmed_primary_17485678
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_17485678
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0610393104
