Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling
Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Neuropeptide signaling requires the presence of G protein-coupled receptors (GPCRs) at the cell surface. Activated GPCRs interact with β-arrestins, which mediate receptor desensitization, endocytosis, and mitogenic signaling, and the peptide-receptor-arrestin complex is sequestered into endosomes. Although dissociation of β-arrestins is required fo...
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Full title
Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling
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Record Identifier
TN_cdi_pubmed_primary_17592116
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_17592116
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.0701910104
