Identification of P2X(4) receptor transmembrane residues contributing to channel gating and interact...
Identification of P2X(4) receptor transmembrane residues contributing to channel gating and interaction with ivermectin
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Germany
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Language
English
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Germany
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Ivermectin (IVM), a large macrocyclic lactone, specifically enhances P2X(4) receptor-channel function by interacting with residues of transmembrane (TM) helices in the open conformation state. In this paper, we used cysteine-scanning mutagenesis of rat P2X(4)-TMs to identify and map residues of potential importance for channel gating and interactio...
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Full title
Identification of P2X(4) receptor transmembrane residues contributing to channel gating and interaction with ivermectin
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TN_cdi_pubmed_primary_18427835
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmed_primary_18427835
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ISSN
0031-6768
DOI
10.1007/s00424-008-0450-4
